By B. Beek
The bioaccumulation of endocrine disruptors, continual natural chemical substances and different compounds of excessive environmental effect has develop into of accelerating curiosity in most modern environmental study, chance research and toxicology. This quantity supplies an up to date assessment and introduces the reader to the hot inspiration of "internal influence focus" linking bioaccumulation and biomagnification within the foodstuff chain to ecotoxicology and probability evaluate.
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Geyer et al. 22 BCF in algae (Chlorella fusca) BCFW: 34 BCFD: 170 BCF in fish (golden ide; uptake 3 days) BCFW: 120q BCFL: 1970q BCF in zebra fish (kinetic approach) BCFW: 74 e BCFL: 1850 e Bioaccumulation and Occurrence of Endocrine-Disrupting Chemicals (EDCs) 4-Octylphenol (OP) 5. 87 2,2-Bis-(3,5-dibromo4-hydroxyphenyl) propane Water Solubility (mg l–1) log KOW Detected in water, sludge, sediment, algae, mussel, or fish. J. Geyer et al. 69 (pH: 7) fresh water, sea water, sediment, mussel, and fish BCF in algae (Chlorella fusca): BCFW: 1,250 BCFD: 7,250 BCF in mussels (Mytilus edulis): BCFW: 170 BCFL: 20,000 (Anodonta anatina) BCFW: 80 BCFL: 7,340 (Pseudanodonta complanata) BCFW: 61 BCFL: 5,690 BCF in fish Golden orfe: BCFW: 219 BCFW: 334 BCFL: 5,000 BCFL: 5,510 Bioaccumulation and Occurrence of Endocrine-Disrupting Chemicals (EDCs) Pentachlorophenol (PCP) Fathead minnow: BCFW: 770 BCFL: 7,330 45 BCF in mussels and fish: BCFW: 50–780 h BCFL: 7,300 i (mean) 46 Table 6 (continued) Chemical (common name, abbreviation, and/or IUPAC name) CAS no Chlordecone 143–50–0 (Kepone®) m 1,1a,3,3a,4,5,5,5a,5b, 6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd] pentalen2-one Chemical structure Molecular formula and molecular mass [g mol–1] RPP a (%) Water Solubility (mg l–1) log KOW Detected in water, sludge, sediment, algae, mussel, or fish.
The evidence suggests that the structure of the Ah receptor is heterogeneous among species. However, it is not known if these structural differences influence species susceptibility to antiestrogenic compounds, such as PCDDs, PCDFs, and PCBs. The Ah receptor is necessary but not sufficient for eliciting some of the toxic and biological responses caused by these compounds. Therefore, other factors are involved in these processes. 3 Chemicals with Androgenic Activity (Xenoandrogens) At this time one known, non-steroidal environmental chemical with androgenic activity is tributyltin (TBT).
M n o p q r s t u v w x y z Relative estrogenic potency compared to 17b-estradiol (100) by molar mass determined with the recombinant yeast cell bioassay (RCBA) [138b]. Trade name. Laboratory model static ecosystem used by Metcalf . It is not possible to calculate “real” steady-state BCF values. The water solubility value seems too high in comparison to the high log KOW value. Relative potency compared to 17b-estradiol (100%). Data from Jobling and Sumpter (1993): Aquat. Toxicol 27: 361. The bioaccumulation included all the metabolites of the test substance because 14C-labeled chemical was used.
Bioaccumulation - New Aspects and Developments by B. Beek