J. F. Theis, C. S. Newlon (auth.), Prof. Dr. Robert Brambl,'s Biochemistry and Molecular Biology PDF

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By J. F. Theis, C. S. Newlon (auth.), Prof. Dr. Robert Brambl, Prof. Dr. George A. Marzluf (eds.)

ISBN-10: 3662103672

ISBN-13: 9783662103678

ISBN-10: 3662103699

ISBN-13: 9783662103692

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Cloned P-ATPase Genes. . . . . . . . . PMAl: The Major Plasma-Membrane Proton Pump. . . . . . . . . . . . . . A. Discovery and Purification . . . . . . . . .. B. Primary Structure and Membrane Topology . . . . . . . . . C. Monomer or Dimer? . . . . . . . . . . .. D. Are There Other Subunits? . .. . . . . . E. Transport Cyde . . . . . . . . . . . . . F. Structure-Function Relationships . . . . . ..

References . . . . . . . . . . . . . . . 29 31 31 31 32 37 37 37 39 40 40 41 42 43 44 45 46 47 47 48 48 49 I. E 2- or P-ATPases are a large and physiologically important family of cation pumps, widely distributed in both prokaryotic and eukaryotic cells (Table 1). In eubacteria, they play aseries of specialized roles: scavenging potassium ions from the medium under conditions of K+ starvation, accumulating M g2+, regulating the cyto- 1 Department of Physiology, lohns Hopkins University School of Medicine, Baltimore, MD 21205, USA 2 Departments of Genetics and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06517, USA plasmic Ca2+ and Cu2+ concentrations, and ridding the cell of toxic heavy met als such as Cd2+ and Zn2+.

G. Biogenesis . . . . . . . . . . . . . . . .. H. Regulation. . . . . . . . . . . . . . . IV. PMA2: an Alternative Proton Pump ......... V. PMRl: a Putative Golgi-Based Ca2+ATPase in Saccharomyces cerevisiae . . . . VI. PMR2/ENA: a Putative Na+ Efflux System in Saccharomyces cerevisiae . . . . . . . . VII. PMCl: a Vacuolar Ca2+ Pump in Saccharomyces cerevisiae . . . . . . . . VIII. CTA3: an Endomembrane Ca2+ Pump in Schizosaccharomyces pombe . .

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Biochemistry and Molecular Biology by J. F. Theis, C. S. Newlon (auth.), Prof. Dr. Robert Brambl, Prof. Dr. George A. Marzluf (eds.)


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