Cardiac Regeneration and Repair. Pathology and Therapies by R-K Li and R.D. Weisel (Eds.) PDF

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By R-K Li and R.D. Weisel (Eds.)

ISBN-10: 0857096583

ISBN-13: 9780857096586

Cardiac Regeneration and service, quantity One stories the pathology of cardiac damage and the most recent advances in mobile therapy.

Chapters partially one discover the pathogenesis of congestive middle failure, the mechanisms accountable for adversarial cardiac matrix home improvement, and power interventions to revive ventricular functionality. half highlights new methods to phone treatment for cardiac regeneration, and contains chapters overlaying alternative ways of phone supply, tracking cellphone engraftment, and the feasibility of utilizing allogeneic stem cells to revive cardiac functionality. Chapters partly 3 flow directly to spotlight novel stem cells for cardiac fix, together with human embryonic stem cells and human pluripotent stem cells, and element their present prestige and destiny strength for cardiac remedy. eventually, half 4 explores gene remedy, and contains ultrasound-targeted or direct gene supply in addition to cell-based gene remedy for cardiac regeneration.

Cardiac Regeneration and service, quantity One is complemented through a moment quantity protecting biomaterials and tissue engineering. jointly, the 2 volumes of Cardiac Regeneration and Repair supply a accomplished source for clinicians, scientists, or academicians excited about cardiac regeneration, together with these attracted to mobilephone treatment, tissue engineering, or biomaterials.

  • Explores the pathogenesis of congestive center failure, the mechanisms accountable for hostile cardiac matrix home improvement, and capability interventions to revive ventricular function
  • Highlights new techniques to mobilephone treatment for cardiac regeneration and contains chapters protecting other ways of mobile supply, tracking phone engraftment, and the feasibility of utilizing allogeneic stem cells to revive cardiac function
  • Explores gene remedy and comprises ultrasound-targeted or direct gene supply in addition to cell-based gene remedy for cardiac regeneration

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Additional resources for Cardiac Regeneration and Repair. Pathology and Therapies

Example text

Nat Med 16: 887–896. 97. Libby P and Lee RT. (2000) Matrix matters. Circulation 102: 1874–1876. 98. Pendergraft WF 3rd, Rudolph EH, Falk RJ, et al. (2004) Proteinase 3 sidesteps caspases and cleaves p21(Waf1/Cip1/Sdi1) to induce endothelial cell apoptosis. Kidney Int 65: 75–84. Cardiac matrix remodeling and heart failure 23 99. Bank U, Kupper B, Reinhold D, et al. (1999) Evidence for a crucial role of neutrophilderived serine proteases in the inactivation of interleukin-6 at sites of inflammation.

1 Cardiac work loops for analysis of global and regional mechanics. (a) Sample work loop showing the typical pressure–volume relationship as seen in the healthy heart. Arrows indicate the direction of the loop over time, ‘X’ indicates end diastole for each beat and ‘*’ indicates end systole for each loop. End systolic pressure to volume relationship (ESPVR) is indicated. (b) Typical pressure–area regional work loop measured in the healthy heart. Arrow indicates the direction of the loop, ‘X’ indicates end diastole and ‘*’ indicates end systole.

51. Cleutjens JP, Kandala JC, Guarda E, et al. (1995) Regulation of collagen degradation in the rat myocardium after infarction. J Mol Cell Cardiol 27: 1281–1292. 52. Kim HE, Dalal SS, Young E, et al. (2000) Disruption of the myocardial extracellular matrix leads to cardiac dysfunction. J Clin Invest 106: 857–866. 53. Spinale FG, Coker ML, Bond BR and Zellner JL. (2000) Myocardial matrix degradation and metalloproteinase activation in the failing heart: a potential therapeutic target. Cardiovasc Res 46: 225–238.

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Cardiac Regeneration and Repair. Pathology and Therapies by R-K Li and R.D. Weisel (Eds.)


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