By George A. , Ed. Miller
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Additional resources for Cellular Aspects of HIV Infection
Changes in the viral mRNA expression pattern correlate with a rapid rate of CD4 T cell number decline in human immunode®ciency virus type 1-infected individuals. J Virol 69: 2092±2100. 10 HIV and Virus-Host Interplay Ganeshan S, Dickover RE, Korber BT, Bryson YJ, Wolinsky SM. 1997. Human immunode®ciency virus type 1 genetic evolution in children with di¨erent rates of development of disease. J Virol 71: 663±677. Goodenow M, Huet T, Saurin W, Kwok S, Sninsky J, Wain-Hobson S. 1989. HIV-1 isolates are rapidly evolving quasispecies: evidence for viral mixtures and preferred nucleotide substitutions.
The vast majority of quantitative studies carried out in vivo have highlighted the role of cell-free viremia as a reliable index of mean viral activity in HIV infection. , 1996) the disease progression. These ®ndings have greatly contributed in the last few years to a clearer understanding of the virologic correlates of disease progression, to driving new attempts at understanding the pathogenic potential of HIV, and to designing e¨ective antiretroviral strategies. Although recent research has highlighted the diagnostic role of other quantitative parameters, including viral transcription pattern and provirus copy numbers, and although in some cases virus compartmentalization may in¯uence the exact correspondence between cell-free plasma viremia and systemic viral activity, the analysis of viral genome molecules in plasma samples is still a major molecular correlate of systemic viral activity at the level of the whole body in many human viral infections.
1997. Human immunode®ciency virus type 1 genetic evolution in children with di¨erent rates of development of disease. J Virol 71: 663±677. Goodenow M, Huet T, Saurin W, Kwok S, Sninsky J, Wain-Hobson S. 1989. HIV-1 isolates are rapidly evolving quasispecies: evidence for viral mixtures and preferred nucleotide substitutions. J Acquired Immune De®c Syndr 2: 344±352. Hahn BH, Shaw GM, Taylor ME, Red®eld RR, Markham PD, Salahuddin SZ, Wong-Staal F, Gallo RC, Parks ES, Parks WP. 1996. Genetic variation in HTLV III/LAV over time in patients with AIDS or at risk for AIDS.
Cellular Aspects of HIV Infection by George A. , Ed. Miller