By Edgar Jacoby
Within the post-genomic period, one of many key demanding situations for drug discovery is making optimum use of the great genomic facts on hand after the elucidation of the human genome and others which will determine powerful new drugs. Addressing this problem, chemogenomics goals to spot systematically all ligands and modulators for all of the gene items expressed and permits the sped up exploration in their organic functionality. the topic brings jointly various disciplines together with chemistry, genetics, chemo- and bioinformatics, structural biology, and organic screening in phenotypic and target-based assays.This ebook uniquely integrates experiences of the most recent state of the art examine through leaders within the quite a few disciplines, offering a common, knowledge-centric evaluation of different chemical, organic and informatics elements. in contrast to current guides, the booklet specializes in how those disciplines engage successfully for the quick discovery of latest goals and their effector molecules at the same time. Examples of chemogenomics techniques pursued in academia in addition to in biotech and pharmaceutical businesses also are supplied.
Read or Download Chemogenomics: Knowledge-Based Approaches to Drug Discovery PDF
Best biochemistry books
Clutch biochemistry fundamentals, follow the technology, and ace your exams
Are you baffled via biochemistry? if that is so here's the good news ? you don't need to remain that manner! exhibits you ways to get a deal with on biochemistry, practice the technology, bring up your grades, and get ready your self to ace any standardized test.
This pleasant, unintimidating consultant offers an outline of the cloth coated in a regular college-level biochemistry path and makes the topic effortless to appreciate and obtainable to all people. From mobile ultrastructure and carbohydrates to amino acids, proteins, and supramolecular constitution, you'll establish biochemical constructions and reactions, and ship your grades soaring.
Newest biology, biochemistry, chemistry, and medical discoveries
Updated examples and explanations
Incorporates the most up-tp-date instructing techniques
From water biochemistry to protein synthesis, provides the very important details, transparent causes, and significant insights you must elevate your realizing and enhance your functionality on any biochemistry try.
So much info on yeasts derives from experiments with the traditional yeasts Saccaromyces cerevisiae and Schizossaccharomyces pombe, the full nuclear and mitochondrial genome of which has additionally been sequenced. For all different non-conventional yeasts, investigations are in development and the quick improvement of molecular options has allowed an perception additionally right into a number of non-conventional yeasts.
- Rings that are nearly associative
- Kinase Screening and Profiling: Methods and Protocols
- Biochemische Labormethoden
- Infinite crossed products
- The TNF Superfamily: Methods and Protocols
- Progress in Medicinal Chemistry, Vol. 36
Extra info for Chemogenomics: Knowledge-Based Approaches to Drug Discovery
317–332. Wiley-VCH, Weinheim. 75. Oprea TI, Matter H. (2004) Integrating virtual screening in lead discovery. Curr. Opin. Chem. Biol. 8:349–358. 76. Hert J, Willett P, Wilton D, et al. (2004) Topological descriptors for similaritybased virtual screening using multiple bioactive reference structures. Org. Biomol. Chem. 2:3256–3266. ch01 FA April 1, 2006 34 15:40 WSPC/Book-329: Chemogenomics: An Emerging Strategy for Rapid Target and Drug Discovery E. Jacoby et al. 77. Schuffenhauer A, Popov M, Schopfer U, et al.
J. Med. Chem. 47:4891–4896. 104. Guba W, Roche O. (2004) Computational ﬁlters in lead generation: Targeting drug-like chemotypes. In: H Kubini, G Müller (eds), Chemogenomics in Drug Discovery — A Medicinal Chemistry Perspective, pp. 325–339. Wiley-VCH, Weinheim. 105. Jacoby E, Schuffenhauer A, Popov M, et al. (2004) Molecular informatics as an enabling in silico technology platform for drug discovery. Chimia 58: 577–584. 106. Wilkens SJ, Janes J, Su AL. (2005) HierS: Hierarchical scaffold clustering using topological chemical graphs.
119. Veber DF, Johnson SR, Cheng HY, et al. (2002) Molecular properties that inﬂuence the oral bioavailability of drug candidates. J. Med. Chem. 45: 2615–2623. 120. Lu JJ, Crimin K, Goodwin JT, et al. (2004) Inﬂuence of molecular ﬂexibility and polar surface area metrics on oral bioavailability in the rat. J. Med. Chem. 47:6104–6107. 121. Vieth M, Siegel MG, Higgs RE, et al. (2005) Characteristic physical properties and structural fragments of marketed oral drugs. J. Med. Chem. 47:224–232. 122.
Chemogenomics: Knowledge-Based Approaches to Drug Discovery by Edgar Jacoby