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By James F. Holland M. D. (auth.), James F. Holland M. D., Myroslaw M. Hreshchyshyn M. D. (eds.)

ISBN-10: 3642859070

ISBN-13: 9783642859076

ISBN-10: 3642859097

ISBN-13: 9783642859090

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Additional resources for Choriocarcinoma: Transactions of a Conference of the International Union against Cancer

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Metastatic choriocarcinoma without primary lesion. Obstet. Gynec. 13,737-740 (1959). 44 DONALD P. C. CHAN: The Natural History of Choriocarcinoma ATTWOOD, H. , and PARK, W. , Embolism to the lungs by trophoblast. J. Obstet. Gynaec. Brit. Cwlth. 68,611 (1961). BARDAWIL, W. , and Toy, B. , The natural history of choriocarcinoma: Problems of immunity and spontaneous regression. Ann. N. Y. Acad. Sci. 80, 197-257 (1959). CHAN, D. P. , Choriocarcinoma. A study of 41 cases. Brit. med. j. 1962 II, 953-957.

When its epithelial covering - the syncytiotrophoblasts or the syncytio- and cytotrophoblasts (Langhans cell layer) are proliferative and consist of several layers, then the mole can be recognized as malignant, and it can either perforate the uterine wall or metastasize by way of the circulation, and rarely by the lymphatics. The emboli may be deposited in any organ where they ultimately grow into either chorioadenoma destruens or choriocarcinoma. 3 Choriocarcinoma Our records show that the most frequent target of first metastasis is the lungs, then the vagina.

Results and discussion The seven successfully established strains of choriocarcinoma resulted from a total of thirty attempts. Five of these Roy HERTZ: 28 the same for previously frozen tissue as well. Histological study of all strains reveals a close similarity in morphology of the transplant with that seen in the original human material. The rich vascularity of the tumor is very striking, the vascular elements and extravasated blood constituting about half of the tumor mass. Both cytotrophoblast and syncytiotrophoblast strains "took" initially in totally untreated hamsters and all but one strain can be maintained in such untreated animals.

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Choriocarcinoma: Transactions of a Conference of the International Union against Cancer by James F. Holland M. D. (auth.), James F. Holland M. D., Myroslaw M. Hreshchyshyn M. D. (eds.)


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