By Giovanni Floris, Bruno Mondovi
Although the volume of study on copper amine oxidases has grown quickly and considerably some time past decade, the sector regrettably suffers from loss of solidarity and critical confusion surrounds facets so simple as affirmation of enzyme identities. This ebook describes the constitution of the enzymes, the function of copper, and of the bizarre cofactor 6-hydroxydopa quinine derived from a posttranslational amendment of a tyrosine residue. It additionally covers the diversities of among AOs from micro organism, crops, and mammals. eventually, the textual content examines the significance of this ubiquitous classification of enzymes in body structure and in metabolism of biogenic amines.
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Extra resources for Copper amine oxidases : structures, catalytic mechanisms, and role in pathophysiology
Y includes the enzymes oxidizing CH–NH2 groups. y includes those that use oxygen as the acceptor. The final (y) number specifies the individual enzyme within the group. The correct use of this system should mean that the enzyme or group of enzymes cited should be perfectly described by the “accepted name,” EC number, and source. The difficulty is sometimes knowing the correct substrate(s) to choose in cases of enzymes that have broad specificities. 2 lists information about each of the enzymes currently recognized as amine oxidases.
2004), but the extent to which such inactivation may occur in vivo is unknown. , 2004) that are inhibitors of sodium-transporting systems and have been used as diuretic and antihypertensive agents. The relative contributions of each of these enzymes in this respect is unknown but the plasma and endothelial surface locations of PrAO may make it more important for binding such drugs in the circulation. , 1998). The significance of this binding, which may either activate or inhibit amine oxidase activity (Holt et al,.
The nonphysiological amine benzylamine was shown to be a good substrate for mammalian enzymes. Because of this, plasma SSAO has been called benzylamine oxidase. However, benzylamine is also a substrate for DAO and one of the two isoenzymes of MAO. Substrates that have been shown to be oxidized by SSAO and not by MAO include methylamine and aminoacetone. Thus, one of those might be used in a name, but that would tend to obscure the broad substrate specificity. , 1993). The most consistent difference between MAO and SSAO appears to be the ability of the former to catalyze the oxidation of secondary amines such as adrenaline and Nomenclature and Potential Functions of Copper Amine Oxidases 11 some tertiary amines.
Copper amine oxidases : structures, catalytic mechanisms, and role in pathophysiology by Giovanni Floris, Bruno Mondovi