By Aydin Arici
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Extra resources for Current Opinion in Obstetrics & Gynecology JUNE 2010
In both studies, all patients underwent follicular aspiration without flushing. Patients who had no oocyte recovered from aspiration alone were changed to the flushing group. Patients who still had no oocyte after aspiration and flushing were not included in the analysis. Such an experimental design makes definitive conclusions difficult and highlights the need for randomized controlled trials. However, these data suggest a potential for benefit with follicular flushing in patients undergoing seminatural or minimal stimulation ART.
At this time, daily gonadotropins and a gonadotropin-releasing Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. Benefits of follicular flushing Hill and Levens 211 antagonist were administered. Human chorionic gonadotropin was given for oocyte maturation when the lead follicle was more than 16 mm in diameter and oocyte retrieval was performed 34 h later. Although the majority of the outcomes were similar between oocytes derived from flushing and aspiration only, the flushing group demonstrated increased top quality embryos and implantation rates of embryos derived from oocytes obtained from follicular flushing.
However, definitive conclusions regarding follicular flushing in these populations cannot be made at the present time. There is a need for adequately powered, randomized, controlled trials in the populations most likely to benefit from an increased oocyte yield, including poor responders, IVM, minimal stimulation, and natural cycle ART patients. Acknowledgements The authors would like to thank Mary Ryan, MLS at the National Institutes of Health Library for her valuable assistance with the literature search in the preparation of this manuscript.
Current Opinion in Obstetrics & Gynecology JUNE 2010 by Aydin Arici